A novel role analysis method for network domain users was proposed.Firstly,the algorithm used ISODATA algorithm to cluster network events for user behavior analysis,on the basis of conditions,the method search relationships between varieties of grouping Shower Gel sets in the network instance,and identify each user role in the performing process of
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
Background The failure of conventional therapies and the propensity for recurrence and metastasis make triple-negative breast cancer (TNBC) a formidable challenge with grim prognoses and diminished survival rates.Immunotherapy, including immune checkpoint blockade and chimeric antigen receptor (CAR)-T cell therapy, presents innovative and potential
Oxidative Cellular Damage and the Reduction of APE/Ref-1 Expression after Experimental Traumatic Brain Injury
The DNA repair enzyme, apurinic/apyrimidinic endonuclease (or redox effector factor-1, APE/Ref-1), is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage.We investigated the expression of APE/Ref-1 and its relationship to oxidative stress after severe traumatic brain injury produced by controlled cortical impa
Quality of Life in Men With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a disorder of adrenal steroid biosynthesis, leading to hypocortisolism, hypoaldosteronism, and hyperandrogenism.Impaired quality of life (QoL) has been demonstrated in women with CAH, but data on men with CAH are scarce.We hypothesized that disease severity and poor tr
Power Line Communication Applied in a Typical Brazilian Urban Power Network
Smart Grids are composed of many features and new technologies which are gradually incorporated to traditional electrical networks.Smart Metering is one of these new features, it remotely manages consumers, enables fraud prevention, identifies faults and shutdowns, and manages distribution transformers, among others.In this context, this paper pres